Xylometazoline Loaded Chitosan Nanoparticles: Fabrication, Optimization and Evaluation for Nasal Congestion

Abstract: Aim: The present study aims at exploring the development of xylometazoline hydrochloride loaded chitosan nanoparticles (XYL-NP) cross linked with calcium chloride for treatment nasal congestion. Materials and Methods: XYL-NP were prepared using different polymer like chitosan, linking agent glacial acetic acid as a solvent enhancer ionotropic gelation method, which was further optimized validated by Box-Behnken Design. Further, these particles characterised size, morphology evaluated its release permeability studies. Results: showed particle size 172+0.4 nm PDI 0.27. obtained charged encapsulation efficiency 90.5%. Transmission Electron Microscopy (TEM) Scanning (SEM) studies have small smooth an in-vitro drug 81.2 %, following Peppas-korsemeyer model.96.3% permeated through mucosa goat in time period 8 hr. Conclusion: Release permeation results shows capability to retain large amount inside mucosa. Hence can be used treating congestion fabricated formulation has good bioadhesive mucoadhesive property. Keywords: Xylometazoline hydrochloride, Nasal Congestion, Chitosan, Box-Behken Design, Calcium Chloride, Ionic gelation, Peppas-korsemeyer.